VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines

VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) involvement has been established in the oncogenic cell signaling of acute myeloid leukemia (AML) cells and in the crosstalk with their niche. We have shown an expression of NOX subunits in AML cell lines while NOX activity is lacking...

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Bibliographic Details
Main Authors: Maya El Dor, Hassan Dakik, Marion Polomski, Eloi Haudebourg, Marie Brachet, Fabrice Gouilleux, Gildas Prié, Kazem Zibara, Frédéric Mazurier
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
VAS3947
NADPH oxidases
leukemia
cysteine thiol alkylation
oxidative stress
endoplasmic reticulum
Online Access:https://www.mdpi.com/1422-0067/21/15/5470

Internet

https://www.mdpi.com/1422-0067/21/15/5470

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