Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability,...

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Bibliographic Details
Main Authors: Ayla Yalamanoglu, Irina L. Dubach, Nadja Schulthess, Giada Ingoglia, Delaney C. Swindle, Rok Humar, Dominik J. Schaer, Paul W. Buehler, David C. Irwin, Florence Vallelian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
sickle cell anemia
CD40
macrophage
liver disease (Ld)
vasoocclusive crisis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627944/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.627944/full

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