Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK pathway. Here we used varying doses of two agents, Mito-Paraquat and Mito-M...

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Bibliographic Details
Main Authors: Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C. Hartley, Michael P. Murphy, Narayan G. Avadhani
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Mitochondrial ROS
Calcineurin activation
HIF1α
Retrograde signaling
Hypoxia mediated stress
Macrophage cell line
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308119

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http://www.sciencedirect.com/science/article/pii/S2213231720308119

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