The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells

The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells

Abstract Background Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA pr...

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Bibliographic Details
Main Authors: Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit, Yasusei Kudo
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cancer
Subjects:
Cancer-associated fibroblasts
microRNA (miRNA)
Cholangiocarcinoma
PAI-2
Migration
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s12943-018-0760-x

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http://link.springer.com/article/10.1186/s12943-018-0760-x

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