Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in the propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibitors protect against APAP injury. However, later work demonstrated that macro...

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Bibliographic Details
Main Authors: Melissa M. Clemens, Joel H. Vazquez, Stefanie Kennon-McGill, Sandra S. McCullough, Laura P. James, Mitchell R. McGill
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-09-01
Series:Liver Research
Subjects:
Acetaminophen (APAP)
Acute liver failure (ALF)
Damage-associated molecular patterns (DAMPs)
Drug-induced liver injury
Liposomal clodronate (LC)
Kupffer cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568420300362

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http://www.sciencedirect.com/science/article/pii/S2542568420300362

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