Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Abstract Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism is not fully understood, hindering the development of targeted therapy. Metabolic abnormalities are a hallmark of cancer. Targeting dysregulated metabolic features has bec...

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Bibliographic Details
Main Authors: Luwei He, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao, Moubin Lin
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Cancer Communications
Subjects:
calcitriol
cell proliferation
cholesterol biosynthesis
colorectal cancer
CYP24A1
MAPK signaling
Online Access:https://doi.org/10.1002/cac2.12187

Internet

https://doi.org/10.1002/cac2.12187

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