A Comparative pO2 Probe and [18F]-Fluoro-Azomycinarabino-Furanoside ([18F]FAZA) PET Study Reveals Anesthesia-Induced Impairment of Oxygenation and Perfusion in Tumor and Muscle.

A Comparative pO2 Probe and [18F]-Fluoro-Azomycinarabino-Furanoside ([18F]FAZA) PET Study Reveals Anesthesia-Induced Impairment of Oxygenation and Perfusion in Tumor and Muscle.

CT26 colon carcinoma-bearing mice were anesthetized with isoflurane (IF) or ketamine/xylazine (KX) while breathing air or oxygen (O2). We performed 10 min static PET scans 1 h, 2 h and 3 h after [18F]FAZA injection and calculated the [18F]FAZA-uptake and tumor-to-muscle ratios (T/M). In another expe...

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Bibliographic Details
Main Authors: Moritz Mahling, Kerstin Fuchs, Wolfgang M Thaiss, Florian C Maier, Martina Feger, Daniel Bukala, Maren Harant, Martin Eichner, Jörg Reutershan, Florian Lang, Gerald Reischl, Bernd J Pichler, Manfred Kneilling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4406741?pdf=render

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http://europepmc.org/articles/PMC4406741?pdf=render

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