Two chromogranin a-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2.

BACKGROUND: Antimicrobial peptides derived from the natural processing of chromogranin A (CgA) are co-secreted with catecholamines upon stimulation of chromaffin cells. Since PMNs play a central role in innate immunity, we examine responses by PMNs following stimulation by two antimicrobial CgA-deri...

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Main Authors: Dan Zhang, Peiman Shooshtarizadeh, Benoît-Joseph Laventie, Didier André Colin, Jean-François Chich, Jasmina Vidic, Jean de Barry, Sylvette Chasserot-Golaz, François Delalande, Alain Van Dorsselaer, Francis Schneider, Karen Helle, Dominique Aunis, Gilles Prévost, Marie-Hélène Metz-Boutigue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2639705?pdf=render