Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation

Antibodies raised against human α2-6 and β2-4 nicotinic receptor subunits were utilized to fractionate 3H-epibatidine binding in human temporal cortex and striatum. The predominant receptor subtypes in both regions contained α4 and β2 subunits. In normal cortex, 10% of binding was also associated wi...

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Bibliographic Details
Main Authors: Cecilia Gotti, Milena Moretti, Iwo Bohr, Iryna Ziabreva, Silvia Vailati, Renato Longhi, Loredana Riganti, Annalisa Gaimarri, Ian G. McKeith, Robert H. Perry, Dag Aarsland, Jan Petter Larsen, Emanuele Sher, Ruth Beattie, Francesco Clementi, Jennifer A. Court
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Nicotinic acetylcholine receptors
Subunits
Human brain
Alzheimer's disease
Parkinson's disease
Dementia with Lewy bodies
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000908

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http://www.sciencedirect.com/science/article/pii/S0969996106000908

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