Combination Cell Therapy Using Mesenchymal Stem Cells and Regulatory T-Cells Provides a Synergistic Immunomodulatory Effect Associated with Reciprocal Regulation of Th1/Th2 and Th17/Treg Cells in a Murine Acute Graft-Versus-Host Disease Model

Combination Cell Therapy Using Mesenchymal Stem Cells and Regulatory T-Cells Provides a Synergistic Immunomodulatory Effect Associated with Reciprocal Regulation of Th1/Th2 and Th17/Treg Cells in a Murine Acute Graft-Versus-Host Disease Model

Mesenchymal stem cells (MSCs) have been considered to be an ideal cellular source for graft-versus-host disease (GVHD) treatment due to their unique properties, including tissue repair and major histocompatibility complex (MHC)-unmatched immunosuppression. However, preclinical and clinical data have...

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Bibliographic Details
Main Authors: Jung-Yeon Lim, Min-Jung Park, Keon-Il Im, Nayoun Kim, Eun-Joo Jeon, Eun-Jung Kim, Mi-La Cho, Seok-Goo Cho M.D., Ph.D
Format: Article
Language:English
Published: SAGE Publishing 2014-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368913X664577

Internet

https://doi.org/10.3727/096368913X664577

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