Systematic Evaluation of Kinetics and Distribution of Muscle and Lymph Node Activation Measured by 18F-FDG- and 11C-PBR28-PET/CT Imaging, and Whole Blood and Muscle Transcriptomics After Immunization of Healthy Humans With Adjuvanted and Unadjuvanted Vaccines

Systematic Evaluation of Kinetics and Distribution of Muscle and Lymph Node Activation Measured by 18F-FDG- and 11C-PBR28-PET/CT Imaging, and Whole Blood and Muscle Transcriptomics After Immunization of Healthy Humans With Adjuvanted and Unadjuvanted Vaccines

Systems vaccinology has been applied to detect signatures of human vaccine induced immunity but its ability, together with high definition in vivo clinical imaging is not established to predict vaccine reactogenicity. Within two European Commission funded high impact programs, BIOVACSAFE and ADITEC,...

Full description

Bibliographic Details
Main Authors: Zarni Win, January Weiner 3rd, Allan Listanco, Neva Patel, Rohini Sharma, Aldona Greenwood, Jeroen Maertzdorf, Hans-Joachim Mollenkopf, Kat Pizzoferro, Thomas Cole, Caroline L. Bodinham, Stefan H. E. Kaufmann, Philippe Denoel, Giuseppe Del Giudice, David J. M. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
PET/CT (positron emission tomography/computed tomography)
transcriptomics
systems vaccinology
reactogenicity
muscle
fluorodeoxyglucose (F-FDG) 18
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.613496/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.613496/full

Similar Items