The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility

Background: Recently, the expression of proteinase-activated receptor 2 (PAR2) has been shown to be essential for activin receptor-like kinase 5 (ALK5)/SMAD-mediated signaling and cell migration by transforming growth factor (TGF)-β1. However, it is not known whether activation of non-SMAD TGF-β sig...

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Bibliographic Details
Main Authors: Hendrik Ungefroren, David Witte, Christian Fiedler, Thomas Gädeken, Roland Kaufmann, Hendrik Lehnert, Frank Gieseler, Bernhard H. Rauch
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
ALK5
ERK
cell migration
PAR2
SMAD
transforming growth factor-β
Online Access:https://www.mdpi.com/1422-0067/18/12/2776

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https://www.mdpi.com/1422-0067/18/12/2776

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