Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age

Ras homolog enriched in striatum (Rhes) is a protein that exerts important physiological functions and modulates psychostimulant drug effects. On this basis, the object of this study was to assess 3,4-methylenedioxymethamphetamine (MDMA) effects on microglial (CD11b) and astroglial (GFAP) activation...

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Bibliographic Details
Main Authors: Giulia Costa, Pier Francesca Porceddu, Marcello Serra, Maria Antonietta Casu, Valentina Schiano, Francesco Napolitano, Annalisa Pinna, Alessandro Usiello, Micaela Morelli
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
astrocytes
microglia
neurodegeneration
dopamine
MDMA
Rhes knockout mice
psychosis
Online Access:https://www.mdpi.com/1422-0067/20/7/1556

Internet

https://www.mdpi.com/1422-0067/20/7/1556

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