Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

Inhibition of Carbonic Anhydrases (CAs) has been clinically exploited for many decades for a variety of therapeutic applications. Within a research project aimed at developing novel classes of CA inhibitors (CAIs) with a proper selectivity for certain isoforms, a series of derivatives featuring the...

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Bibliographic Details
Main Authors: Ciro Milite, Giorgio Amendola, Alessio Nocentini, Silvia Bua, Alessandra Cipriano, Elisabetta Barresi, Alessandra Feoli, Ettore Novellino, Federico Da Settimo, Claudiu T. Supuran, Sabrina Castellano, Sandro Cosconati, Sabrina Taliani
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
carbonic anhydrase inhibitors
benzimidazole-sulfonamides
reduced flexibility approach
isoform-selective inhibitors
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2019.1666836

Internet

http://dx.doi.org/10.1080/14756366.2019.1666836

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