Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

Abstract Background The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC). Methods Dual-colour silver-enhanced in situ hybridization was performed in tissue samples of 334 primary CRC patients. The amp...

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Bibliographic Details
Main Authors: Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim, Hye Seung Lee
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Translational Medicine
Subjects:
Gene copy number variation
EGFR
HER2
c-MYC
MET
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12967-017-1265-x

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http://link.springer.com/article/10.1186/s12967-017-1265-x

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