Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Abstract Background Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified. Methods The regulatory role for mTORC1 in Skp2 stability was tested using ubiquitination assay. The func...

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Bibliographic Details
Main Authors: Qirong Geng, Jianjun Liu, Zhaohui Gong, Shangxiang Chen, Shuai Chen, Xiaoxing Li, Yue Lu, Xiaofeng Zhu, Hui-kuan Lin, Dazhi Xu
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Cancer
Subjects:
mTORC1
Phosphorylation
Skp2
Gastric cancer
Online Access:http://link.springer.com/article/10.1186/s12943-017-0649-0

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http://link.springer.com/article/10.1186/s12943-017-0649-0

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