A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region (“NRR”)-Missense Activity in Caenorhabditis elegans

A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region (“NRR”)-Missense Activity in Caenorhabditis elegans

Genetic analysis of LIN-12/Notch signaling in C. elegans has provided many insights into human biology. Activating missense mutations in the Negative Regulatory Region (NRR) of the ectodomain of LIN-12/Notch were first described in C. elegans, and similar mutations in human Notch were later found to...

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Bibliographic Details
Main Authors: Yuting Deng, Katherine Leisan Luo, Daniel D. Shaye, Iva Greenwald
Format: Article
Language:English
Published: Oxford University Press 2019-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
notch
lin-12
kinase
c. elegans
negative regulator
wnk-1
kin-3
hpo-11
mig-15
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400471

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http://g3journal.org/lookup/doi/10.1534/g3.119.400471

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