Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

<p>Abstract</p> <p>Background</p> <p>Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transpor...

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Bibliographic Details
Main Authors: Trdan Lušin Tina, Stieger Bruno, Marc Janja, Mrhar Aleš, Trontelj Jurij, Zavratnik Andrej, Ostanek Barbara
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Translational Medicine
Subjects:
Raloxifene
Raloxifene diglucuronide
SLCO1B1
SLCO1B3
Osteoporosis
LC/MS/MS
Online Access:http://www.translational-medicine.com/content/10/1/76

Internet

http://www.translational-medicine.com/content/10/1/76

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