Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.

Sirtuins and hypoxia-inducible transcription factors (HIF) have well-established roles in regulating cellular responses to metabolic and oxidative stress. Recent reports have linked these two protein families by demonstrating that sirtuins can regulate the activity of HIF-1 and HIF-2. Here we invest...

Full description

Bibliographic Details
Main Authors: Alexander Laemmle, Antje Lechleiter, Vincent Roh, Christa Schwarz, Simone Portmann, Cynthia Furer, Adrian Keogh, Mario P Tschan, Daniel Candinas, Stephan A Vorburger, Deborah Stroka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316573?pdf=render

Internet

http://europepmc.org/articles/PMC3316573?pdf=render

Similar Items