Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.

Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.

The pathogenic fungus Candida albicans switches from yeast growth to filamentous growth in response to genotoxic stresses, in which phosphoregulation of the checkpoint kinase Rad53 plays a crucial role. Here we report that the Pph3/Psy2 phosphatase complex, known to be involved in Rad53 dephosphoryl...

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Bibliographic Details
Main Authors: Haitao Wang, Jiaxin Gao, Wanjie Li, Ada Hang-Heng Wong, Kangdi Hu, Kun Chen, Yue Wang, Jianli Sang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3351423?pdf=render

Internet

http://europepmc.org/articles/PMC3351423?pdf=render

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