Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases

Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery. While some LSDs can be efficiently treated by e...

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Bibliographic Details
Main Authors: Julia Sellin, Heike Schulze, Marie Paradis, Dominic Gosejacob, Cyrus Papan, Andrej Shevchenko, Olympia Ekaterina Psathaki, Achim Paululat, Melanie Thielisch, Konrad Sandhoff, Michael Hoch
Format: Article
Language:English
Published: The Company of Biologists 2017-06-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/10/6/737