Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

Background and Objective. Progressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with idiopathic pulmonary fibrosis (IPF). Transforming growth factor-β (TGF-β) and NADPH oxidase- (NOX-) derived reactive ox...

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Bibliographic Details
Main Authors: Carmel J. W. Stock, Charalambos Michaeloudes, Patricia Leoni, Andrew L. Durham, Sharon Mumby, Athol U. Wells, Kian Fan Chung, Ian M. Adcock, Elisabetta A. Renzoni, Gisela E. Lindahl
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2019/1484736

Internet

http://dx.doi.org/10.1155/2019/1484736

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