Molecular Dynamics Simulations Capture the Misfolding of the Bovine Prion Protein at Acidic pH
Bovine spongiform encephalopathy (BSE), or mad cow disease, is a fatal neurodegenerative disease that is transmissible to humans and that is currently incurable. BSE is caused by the prion protein (PrP), which adopts two conformers; PrPC is the native innocuous form, which is α-helix rich; and PrPSc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-273X/4/1/181 |