Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated transcriptional profiling analyses to study the...

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Bibliographic Details
Main Authors: Suneng Fu, Jason Fan, Joshua Blanco, Alfredo Gimenez-Cassina, Nika N Danial, Steve M Watkins, Gökhan S Hotamisligil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3426552?pdf=render