PKCδ Promotes High Glucose Induced Renal Tubular Oxidative Damage via Regulating Activation and Translocation of p66Shc

PKCδ Promotes High Glucose Induced Renal Tubular Oxidative Damage via Regulating Activation and Translocation of p66Shc

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Renal tubular injury by overproduction of ROS in mitochondria plays a critical role in the pathogenesis of DKD. Evidences have shown that p66Shc was involved in renal tubular injury via mitochondrial-dependent ROS pr...

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Bibliographic Details
Main Authors: Panai Song, Shikun Yang, Li Xiao, Xiaoxuan Xu, Chengyuan Tang, Yuyan Yang, Mingming Ma, Jiefu Zhu, Fuyou Liu, Lin Sun
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2014/746531

Internet

http://dx.doi.org/10.1155/2014/746531

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