Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

Summary: Exhausted immune responses to chronic diseases represent a major challenge to global health. We study CD4+ T cells in a mouse model with regulatable antigen presentation. When the cells are driven through the effector phase and are then exposed to different levels of persistent antigen, the...

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Bibliographic Details
Main Authors: Anne Trefzer, Pallavi Kadam, Shu-Hung Wang, Stefanie Pennavaria, Benedikt Lober, Batuhan Akçabozan, Jan Kranich, Thomas Brocker, Naoko Nakano, Martin Irmler, Johannes Beckers, Tobias Straub, Reinhard Obst
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
exhaustion
anergy
tolerance
CD4+ T cells
gene expression
T cell receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000619

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http://www.sciencedirect.com/science/article/pii/S2211124721000619

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