Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Abstract The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apoptosis. The thioredoxin (Trx) and glutaredoxin (Gr...

Full description

Bibliographic Details
Main Authors: Lena Haffo, Jun Lu, Vladimir J. N. Bykov, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman, Arne Holmgren
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-31048-7

Internet

https://doi.org/10.1038/s41598-018-31048-7

Similar Items