Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1

Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1

Human apurinic/apyrimidinic (AP)-endonuclease APE1 is one of the key enzymes taking part in the repair of damage to DNA. The primary role of APE1 is the initiation of the repair of AP-sites by catalyzing the hydrolytic incision of the phosphodiester bond immediately 5′ to the damage. In ad...

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Bibliographic Details
Main Authors: Alexandra A. Kuznetsova, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
AP-endonuclease
DNA repair
exonuclease activity
pre-steady-state kinetics
Online Access:http://www.mdpi.com/1420-3049/23/9/2101

Internet

http://www.mdpi.com/1420-3049/23/9/2101

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