Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Abstract Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory pro-resolving properties. Methods In v...

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Bibliographic Details
Main Authors: Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin, Sheng-xing Zheng
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Respiratory Research
Subjects:
Acute respiratory distress syndrome
Alveolar type II cells
Proliferation
Apoptosis
Epithelial to mesenchymal transition
Online Access:http://link.springer.com/article/10.1186/s12931-019-1158-z

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http://link.springer.com/article/10.1186/s12931-019-1158-z

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