Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA

Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA

Autoantibodies against double-stranded DNA (anti-dsDNA) are a hallmark of systemic lupus erythematosus (SLE). It is well documented that anti-dsDNA reactive B lymphocytes are normally controlled by immune self-tolerance mechanisms operating at several levels. The evolution of high levels of IgG anti...

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Bibliographic Details
Main Authors: Thomas Weisenburger, Bettina von Neubeck, Andrea Schneider, Nadja Ebert, Daniel Schreyer, Andreas Acs, Thomas H. Winkler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
Dnase1l3
anti-DNA autoantibodies
systemic lupus erythematosus
Fcgr2b
germinal center
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01551/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01551/full

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