Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

<p>Abstract</p> <p>Background</p> <p>The human immunodeficiency virus type 1 (HIV-1) Vpu protein degrades CD4 and counteracts a restriction factor termed tetherin (CD317; Bst-2) to enhance virion release. It has been suggested that both functions can be genetically sepa...

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Bibliographic Details
Main Authors: Specht Anke, Iwanski Alicja, Koppensteiner Herwig, Wimmer Peter, Banning Carina, Rajan Devi, Schindler Michael, Sauter Daniel, Dobner Thomas, Kirchhoff Frank
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/7/1/1

Internet

http://www.retrovirology.com/content/7/1/1

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