Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition

Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition

A novel catalyst-free synthetic approach to 1,2,3-triazolobenzodiazepinones has been developed and optimized. The Ugi reaction of 2-azidobenzaldehyde, various amines, isocyanides, and acids followed by microwave-assisted intramolecular azide–alkyne cycloaddition (IAAC) gave a series of target hetero...

Full description

Bibliographic Details
Main Authors: Maryna O. Mazur, Oleksii S. Zhelavskyi, Eugene M. Zviagin, Svitlana V. Shishkina, Vladimir I. Musatov, Maksim A. Kolosov, Elena H. Shvets, Anna Yu. Andryushchenko, Valentyn A. Chebanov
Format: Article
Language:English
Published: Beilstein-Institut 2021-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
click chemistry
microwave chemistry
multicomponent reactions
triazolobenzodiazepines
ugi reaction
Online Access:https://doi.org/10.3762/bjoc.17.57

Internet

https://doi.org/10.3762/bjoc.17.57

Similar Items