The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

Chemoresistance is a major limiting factor that impairs the outcome of non-small cell lung cancer (NSCLC) chemotherapy. Paclitaxel (Tax) induces protective autophagy in NSCLC cells, leading to the development of drug resistance. We recently identified a new autophagy inhibitor (alpha-hederin) and hy...

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Bibliographic Details
Main Authors: Yujuan Zhan, Kun Wang, Qiao Li, Yidan Zou, Bonan Chen, Qing Gong, Hiuting Idy HO, Ting Yin, Fangyuan Zhang, Yuhua Lu, Weijie Wu, Yilin Zhang, Yuhui Tan, Biaoyan Du, Xiaodong Liu, Jianyong Xiao
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-hederin
autophagy inhibition
non-small cell lung cancer
chemotherapy
paclitaxel
synergistic effect
Online Access:http://www.mdpi.com/1422-0067/19/10/3221

Internet

http://www.mdpi.com/1422-0067/19/10/3221

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