Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.

Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.

Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S...

Full description

Bibliographic Details
Main Authors: Inna Y Gong, Ute I Schwarz, Natalie Crown, George K Dresser, Alejandro Lazo-Langner, GuangYong Zou, Dan M Roden, C Michael Stein, Marc Rodger, Philip S Wells, Richard B Kim, Rommel G Tirona
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3218053?pdf=render

Internet

http://europepmc.org/articles/PMC3218053?pdf=render

Similar Items