Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples
Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2011-01-01
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| Series: | Sarcoma |
| Online Access: | http://dx.doi.org/10.1155/2011/834170 |