Endotoxin tolerance variation over 24 h during porcine endotoxemia: association with changes in circulation and organ dysfunction.

Endotoxin tolerance (ET), defined as reduced inflammatory responsiveness to endotoxin challenge following a first encounter with endotoxin, is an extensively studied phenomenon. Although reduced mortality and morbidity in the presence of ET has been demonstrated in animal studies, little is known ab...

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Bibliographic Details
Main Authors: Markus Castegren, Paul Skorup, Miklós Lipcsey, Anders Larsson, Jan Sjölin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23326400/pdf/?tool=EBI