A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction

Protein-protein interactions regulate almost all cellular functions and rely on a fine tune of surface amino acids properties involved on both molecular partners. The disruption of a molecular association can be caused even by a single residue mutation, often leading to a pathological modification o...

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Bibliographic Details
Main Authors: Lorenzo Di Rienzo, Edoardo Milanetti, Claudia Testi, Linda Celeste Montemiglio, Paola Baiocco, Alberto Boffi, Giancarlo Ruocco
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304049