Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.
Metanephric kidney induction critically depends on mesenchymal-epithelial interactions in the caudal region of the nephric (or Wolffian) duct. Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating the Ret receptor expressed in the nephric duct ep...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-12-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2597718?pdf=render |