Activation of CD8<sup>+</sup> T Cell Responses after Melanoma Antigen Targeting to CD169<sup>+</sup> Antigen Presenting Cells in Mice and Humans

Activation of CD8<sup>+</sup> T Cell Responses after Melanoma Antigen Targeting to CD169<sup>+</sup> Antigen Presenting Cells in Mice and Humans

The lack of tumor-reactive T cells is one reason why immune checkpoint inhibitor therapies still fail in a significant proportion of melanoma patients. A vaccination that induces melanoma-specific T cells could potentially enhance the efficacy of immune checkpoint inhibitors. Here, we describe a vac...

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Bibliographic Details
Main Authors: Dieke van Dinther, Miguel Lopez Venegas, Henrike Veninga, Katarzyna Olesek, Leoni Hoogterp, Mirjam Revet, Martino Ambrosini, Hakan Kalay, Johannes Stöckl, Yvette van Kooyk, Joke M. M. den Haan
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
macrophage
dendritic cell
cancer vaccines
melanoma
T cell responses
CD169
Siglec-1
sialoadhesin
Online Access:https://www.mdpi.com/2072-6694/11/2/183

Internet

https://www.mdpi.com/2072-6694/11/2/183

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