Activation of CD8<sup>+</sup> T Cell Responses after Melanoma Antigen Targeting to CD169<sup>+</sup> Antigen Presenting Cells in Mice and Humans
The lack of tumor-reactive T cells is one reason why immune checkpoint inhibitor therapies still fail in a significant proportion of melanoma patients. A vaccination that induces melanoma-specific T cells could potentially enhance the efficacy of immune checkpoint inhibitors. Here, we describe a vac...
Main Authors: | Dieke van Dinther, Miguel Lopez Venegas, Henrike Veninga, Katarzyna Olesek, Leoni Hoogterp, Mirjam Revet, Martino Ambrosini, Hakan Kalay, Johannes Stöckl, Yvette van Kooyk, Joke M. M. den Haan |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-02-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/2/183 |
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