Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials...

Full description

Bibliographic Details
Main Authors: Liliana R. Loureiro, Mylène A. Carrascal, Ana Barbas, José S. Ramalho, Carlos Novo, Philippe Delannoy, Paula A. Videira
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Biomolecules
Subjects:
Tn antigen
Sialyl Tn antigen
immune response
therapeutic antibodies
antibody production
Online Access:http://www.mdpi.com/2218-273X/5/3/1783

Internet

http://www.mdpi.com/2218-273X/5/3/1783

Similar Items