Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma cell line, NCI-H28, with homozygous deletion of the β-catenin gene.

Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma cell line, NCI-H28, with homozygous deletion of the β-catenin gene.

Protease activated receptors (PARs) are G-protein coupled receptors that are activated by an unique proteolytic mechanism. These receptors play crucial roles in hemostasis and thrombosis but also in inflammation and vascular development. PARs have also been implicated in tumor progression, invasion...

Full description

Bibliographic Details
Main Authors: Alessandra Fazzini, Vanessa D'Antongiovanni, Laura Giusti, Ylenia Da Valle, Federica Ciregia, Ilaria Piano, Antonella Caputo, Anna Maria D'Ursi, Claudia Gargini, Antonio Lucacchini, Maria Rosa Mazzoni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4218765?pdf=render

Internet

http://europepmc.org/articles/PMC4218765?pdf=render

Similar Items