Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency

Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency

Niemann-Pick type C (NPC) is a progressive neurodegenerative disease characterized by lysosomal/endosomal accumulation of unesterified cholesterol and glycolipids. Recent studies have shown that plasma cholestane-3β,5α,6β-triol (CT) and 7-ketocholesterol (7-KC) could be potential biomarkers for the...

Full description

Bibliographic Details
Main Authors: Sonia Pajares, Angela Arias, Judit García-Villoria, Judit Macías-Vidal, Emilio Ros, Javier de las Heras, Marisa Girós, Maria J. Coll, Antonia Ribes
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Lipid Research
Subjects:
oxysterols
7-ketocholesterol
high-performance liquid chromatography/electrospray ionization/tandem mass spectrometry
3α,7α,12α-trihydroxycoprostane
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309688

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520309688

Similar Items