RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low magnitude Ca2+ signals in neurons. We reported previously that these Ca2+ signals, which arise from Ca2+ entry and subsequent amplification by Ca2+ release through ryanodine rec...

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Bibliographic Details
Main Authors: Cecilia Hidalgo, Andrea C. Paula-Lima, Carol D. SanMartín, Pablo Veloso, Tatiana Adasme, Pedro Lobos, Barbara Bruna, Jose Galaz, Alejandra García, Steffen Hartel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
endoplasmic reticulum
reactive oxygen species
mitochondrial calcium
antioxidants
Alzheimer’s disease
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00115/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00115/full

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