Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data

Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data

Abstract Endothelins (EDN) are peptide hormones that activate a GPCR signalling system and contribute to several diseases, including hypertension and cancer. Current knowledge about EDN signalling is fragmentary, and no systems level understanding is available. We investigated phosphoproteomic chang...

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Bibliographic Details
Main Authors: Alexander Schäfer, Enio Gjerga, Richard WD Welford, Imke Renz, Francois Lehembre, Peter MA Groenen, Julio Saez‐Rodriguez, Ruedi Aebersold, Matthias Gstaiger
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Molecular Systems Biology
Subjects:
endothelin
GPCR
melanoma
molecular modelling
phosphoproteomics
Online Access:https://doi.org/10.15252/msb.20198828

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