Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.

Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.

BACKGROUND: Recent experimental studies provide evidence indicating that manipulation of the mononuclear phagocyte phenotype could be a feasible approach to alter the severity and persistence of pulmonary injury and fibrosis. Mineralocorticoid receptor (MR) has been reported as a target to regulate...

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Main Authors: Wen-Jie Ji, Yong-Qiang Ma, Xin Zhou, Yi-Dan Zhang, Rui-Yi Lu, Zhao-Zeng Guo, Hai-Ying Sun, Dao-Chuan Hu, Guo-Hong Yang, Yu-Ming Li, Lu-Qing Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3834272?pdf=render

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http://europepmc.org/articles/PMC3834272?pdf=render

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