Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl ra...

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Main Authors:	G. Soloupis, C. Chatziopoulos, D. Hadjipavlou-Litina, A. Geronikaki
Format:	Article
Language:	English
Published:	MDPI AG 2003-06-01
Series:	Molecules
Subjects:	Thiazolyl amides anti-inflammatories antioxidants lipoxygenase inhibitors
Online Access:	http://www.mdpi.com/1420-3049/8/6/472/

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spelling	doaj-5950fb18eb7b43748ad88b77ab76184a2020-11-24T20:56:48ZengMDPI AGMolecules1420-30492003-06-018647247910.3390/80600472Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl PiperazineG. SoloupisC. ChatziopoulosD. Hadjipavlou-LitinaA. Geronikaki4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.http://www.mdpi.com/1420-3049/8/6/472/Thiazolyl amidesanti-inflammatoriesantioxidantslipoxygenase inhibitors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	G. Soloupis C. Chatziopoulos D. Hadjipavlou-Litina A. Geronikaki
spellingShingle	G. Soloupis C. Chatziopoulos D. Hadjipavlou-Litina A. Geronikaki Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine Molecules Thiazolyl amides anti-inflammatories antioxidants lipoxygenase inhibitors
author_facet	G. Soloupis C. Chatziopoulos D. Hadjipavlou-Litina A. Geronikaki
author_sort	G. Soloupis
title	Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_short	Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_full	Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_fullStr	Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_full_unstemmed	Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_sort	synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-piperidine or of 4-n-methyl piperazine
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2003-06-01
description	4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
topic	Thiazolyl amides anti-inflammatories antioxidants lipoxygenase inhibitors
url	http://www.mdpi.com/1420-3049/8/6/472/
work_keys_str_mv	AT gsoloupis synthesisandbiologicalevaluationofnew45disubstitutedthiazolylamidesderivativesof4hydroxypiperidineorof4nmethylpiperazine AT cchatziopoulos synthesisandbiologicalevaluationofnew45disubstitutedthiazolylamidesderivativesof4hydroxypiperidineorof4nmethylpiperazine AT dhadjipavloulitina synthesisandbiologicalevaluationofnew45disubstitutedthiazolylamidesderivativesof4hydroxypiperidineorof4nmethylpiperazine AT ageronikaki synthesisandbiologicalevaluationofnew45disubstitutedthiazolylamidesderivativesof4hydroxypiperidineorof4nmethylpiperazine
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Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

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