Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
Abstract Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder. The disease severity warrants urgent development of disease-modifying therapy, but the disease pathogenesis is still enigmatic. Neurodegeneration in MSA brains is preceded by the emergence of glial cytopla...
Main Authors: | Seiji Kaji, Takakuni Maki, Tomoyuki Ishimoto, Hodaka Yamakado, Ryosuke Takahashi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-02-01
|
Series: | Translational Neurodegeneration |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40035-020-0185-5 |
Similar Items
-
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy
by: Kaji, Seiji
Published: (2018) -
BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy
by: Seiji Kaji, et al.
Published: (2020-07-01) -
Is Multiple System Atrophy a Prion-like Disorder?
by: Kurt A. Jellinger, et al.
Published: (2021-09-01) -
Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis
by: Lisa Fellner, et al.
Published: (2018-05-01) -
Anle138b partly ameliorates motor deficits despite failure of neuroprotection in a model of advanced multiple system atrophy
by: Lisa eFellner, et al.
Published: (2016-03-01)