Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice

Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice

Malaria is caused by infection with Plasmodium parasites and results in significant health and economic impacts. Malaria eradication is hampered by parasite resistance to current drugs and the lack of a widely effective vaccine. Compounds that target epigenetic regulatory proteins, such as histone d...

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Bibliographic Details
Main Authors: Ming Jang Chua, Jiahui Tng, Eva Hesping, Gillian M. Fisher, Christopher D. Goodman, Tina Skinner-Adams, Darren Do, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Katherine T. Andrews
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
P. falciparum
HDAC inhibitor
Malaria
AR-42
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320721000427

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http://www.sciencedirect.com/science/article/pii/S2211320721000427

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