Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies

Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies

Abstract Background Melanoma is a cancer that has a high mortality rate in the absence of targeted therapy. Conventional therapies such as surgery, chemotherapy, and radiotherapy are associated with poor prognosis. The expression of miR-21 appears to be of clinical importance, and the regulation of...

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Bibliographic Details
Main Authors: Shaghayegh Haghjooy Javanmard, Golnaz Vaseghi, Ahmad Ghasemi, Laleh Rafiee, Gordon A. Ferns, Hajar Naji Esfahani, Reza Nedaeinia
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cancer Cell International
Subjects:
Cutaneous melanoma
miRNAs
miR-21
LNA-anti-miR-21
Online Access:http://link.springer.com/article/10.1186/s12935-020-01394-6

Internet

http://link.springer.com/article/10.1186/s12935-020-01394-6

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